Symbol
Name
ID

Map3k7
mitogen-activated protein kinase kinase kinase 7
MGI:1346877

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes	Ulcerative colitis
Disease(s) Associated with MAP3K7	Ulcerative colitis
frontometaphyseal dysplasia 2

Mouse Phenotypes

increased thymocyte apoptosis

decreased B cell proliferation

decreased T cell proliferation

colitis

enlarged spleen

spleen hyperplasia

decreased B-1 B cell number

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

decreased CD4-positive, alpha-beta T cell number

increased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased NK T cell number

increased gamma-delta intraepithelial T cell number

abnormal intraepithelial T cell number

increased memory T cell number

abnormal regulatory T cell number

absent regulatory T cells

decreased T cell number

decreased single-positive T cell number

abnormal T cell morphology

abnormal alpha-beta intraepithelial T cell morphology

abnormal spleen morphology

abnormal B cell physiology

decreased IgG1 level

decreased IgG3 level

decreased IgG level

decreased immunoglobulin level

abnormal CD4-positive, alpha-beta T cell physiology

abnormal T cell activation

abnormal regulatory T cell physiology

increased circulating interleukin-1 beta level

decreased circulating interleukin-10 level

increased circulating tumor necrosis factor level

abnormal cytokine level

enlarged lymph nodes

increased interferon-gamma secretion

increased interleukin-1 beta secretion

decreased interleukin-10 secretion

increased interleukin-10 secretion

increased interleukin-17 secretion

increased interleukin-6 secretion

increased tumor necrosis factor secretion

increased susceptibility to endotoxin shock

increased inflammatory response

liver inflammation

Availability

Mouse Genotype

Map3k7^tm1.1Gkl/Map3k7^tm1.1Gkl
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Map3k7^tm1Aki/Map3k7^tm1Aki
Tg(Lck-cre)1Jtak/0 (conditional)

Map3k7^tm1Aki/Map3k7^tm1Aki
Tg(Alb1-cre)7Gsc/0 (conditional)

Map3k7^tm1Zjc/Map3k7^tm1Zjc
Tg(Lck-cre)548Jxm/0 (conditional)

Cd19^tm1(cre)Cgn/Cd19⁺
Map3k7^tm1Aki/Map3k7^tm1.1Aki (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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